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Retail Price: $59.99
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Product Description  Supplement Facts

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Burn Ultra by Core Nutritionals

Why does it have to be so difficult? You sit there, a bottle of pills in one hand, a tub of powder in the other, staring blankly at a seemingly endless wall of potions, tinctures, and tonics all with one purpose in mind – to improve the way your body looks, and how you feel about it.

But how do you choose? Which is the best, or the worst? For that matter, how do you even decipher what's in the bottle in front of you, when the amount of every ingredient is masked behind a thousand promises and the ever-present, "proprietary blend."

Confused about which "miracle breakthrough," or "huge advance in science" to choose, you select the one that seems the most popular and go home. After three or four weeks, the only thing that's slimmer is your wallet, and you decide that all supplements are worthless.

But what if there was a better, more effective way? What if, instead of promising "breakthroughs," "advances," and "revolutions," a company simply promised clinically-effective ingredients, at clinically-effective servings? What if, instead of shouting about "secrets of the trade," a company admitted there really wasn't any – that the only true secret is who's willing to spend the time, effort, and money, to deliver an amazing product. What if this company – gasp! – told you exactly what was in the product? Wouldn't that be the better way?

Core Nutritionals' Core BURN Ultra powder is that better way. There are no gimmicks here, no tricks and trade secrets. Just the very best, most verified-effective ingredients at serving sizes known to exert powerful effects on the human body. With Core BURN Ultra powder, we have taken many of the same ultra-potent ingredients found in Core BURN, mixed in a few amazing new friends, and put the whole thing in a delicious, convenient, and rapidly-dissolving powder.

In the end, it's your choice: flashy magazine ads, or an unrivaled and extreme thermo that plain, flat-out works as promised. If we had to choose between a slim wallet or a slim waist, we'd choose the latter – because we'd choose Core BURN Ultra.

Scientific Breakdown:

Coleus forskohlii root extract (10% forskolin):
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda.

Due to the ever-increasing interest in the plant's verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.

A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass.

Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy.

In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core BURN Ultra!

Olea europaea leaf extract (20% oleuropein):
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea.

As the fruits, oils and extracts of Olea europaea L. comprise a large part of a significant portion of the world's population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.

Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research in animals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.

Garcinia cambogia fruit extract (50% hydroxycitric acid):
Garcinia cambogia, more commonly known under a variety of names, including the tamarind, is a small tropical fruit endemic to Indonesia. This plant has come under increased media attention over the past few years, due largely to the purported effects of its principal constituent, hyrdoxycitric acid, or HCA.

HCA itself is a derivative of citric acid, and competitively inhibits the enzyme adenosine triphosphatase-citrate-lyase. This enzyme is an extra-mitochondrial enzyme (meaning it sits outside the mitochondria) chiefly responsible for a process known as de novo lipogenesis – or the production of fatty acids from glucose.

Green coffee bean extract (50% chlorogenic acid):
Chlorogenic acids are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea's constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.

Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.

Trials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the products numerous mechanisms of action, rather than a single, isolated cause.

Green tea extract (50% EGCG):
Along with caffeine from the coffee plant, EGCG (Epigallocatechin gallate) from various sub-species of Camilla sinesis (green tea) is perhaps the most widely known and reputable anti-lipogenic and lipolytic agent in the world. Both compounds have well established anti-obesity effects, detailed in a deep body of literature featuring in vitro cell culture, as well as in vivo animal and human trials.

In animal and human studies, green tea generally and EGCG more specifically has been demonstrated to reduce the absorption of dietary lipids and modulate their subsequent metabolism, increase glucose utilization in resting states, as well as initiate de novo lipogenesis in both maximal and submaximal exercise states

A two month dietary intervention, for example, showed that the daily consumption of a catechin-rich tea – EGCG is the most well-known of the catechins – by healthy humans led to a reduction of bodyweight of up to 20%, the consequence of increased lipolysis (as measured by FFA urinary clearance). A separate double-blind, placebo controlled trial using ECGC consumption both with, and without caffeine, demonstrated the increased oxidation of fat within two hours of a meal – at level increases of 49% and 35%, respectively.

These studies suggest that EGCG not only exerts an inhibitory effect on the accumulation of lipids, but that it perhaps actively leads to the hydrolyzation of triglycerides for use as energy in the form of FFAs. In particular, this effect seems to be potentiated in the presence of caffeine ingestion, suggesting a synergistic effect between EGCG and caffeine on the hydrolyzation and subsequent oxidation of triglyceride stores.

Though the mechanism is slightly different, you will recall that forskolin, our first ingredient, works in the same fashion! Again, we have Core Nutritionals' approach of multiple, complementary mechanisms of action coming to the fore.

Raspberry ketone (4-(p-hydroxyphenyl)-2-butanone):
Raspberry ketone is a major aromatic compound found in a wide range of berries, including blueberries, cranberries, and raspberries. Raspberry ketone has been hypothesized to have a lipolytic effect due to its structural similarity to capsaicin and synephrine, compounds with well-established anti-lipolytic actions.

Though limited, recent research on RK suggests the structural similarities between RK and capsaicin/synephrine may result in RK having the same affinity for anti-lipolytic action. In a recent in vivo animal trial, for example, RK was shown to prevent high-fat, diet-induced elevations in body weight and increase lipolysis.

While ongoing research is definitively establishing the mechanism of action for RK, preliminary research suggests it is modulating a compound known as adiponectin – a key adipocytokine and regulator factor for the proliferation (increasing in number) and hypertrophy (growing) of adipocytes (fat cells).

Bacopa monnieri (50% bacosides):
Bacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.

More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy human beings have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb's effect to on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.

Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN Ultra formula may help to smooth the effect curve of the product's stimulants, reducing jitteriness or, "crash."

Higenamine (Norcoclaurine):
Higenamine, less commonly known as "norcoclaurine," is an isoquinoline chemical compound found naturally in a large range of plants, including in the seeds of Nelumbo nucifera (Lotus).

While not extensive, the emerging animal literature on norcoclaurine suggests that it is a potent beta-2 adrenergic receptor agonist (it activates the receptor). Norcoclaurine's beta-2 adrenergic agonism is at least partially the result of its actions on the enzyme adenylate cyclase. Adenylate cyclase is the rate-limiting enzyme in the production of the critical secondary messenger cAMP (cyclic adenosine monophosphate), a compound involved in the function and regulation of a wide number of receptor and cell types.

Likely as a consequence of its cAMP-raising capacities, norcoclaurine has been shown to relax, rather than constrict, the vasculature (vasodilation). In animal models, norcoclaurine was shown to relax the corpus cavernosum.

Additionally, both caffeine/theobromine and forskolin are also powerful cAMP activators – meaning that already three of Core BURN Ultra's key ingredients are effecting one of the body's most potent lipolytic (the breakdown of fat) pathways. This level of specific, physiological targeting is key in a product of this type, as it allows for a multi-faceted approach to achieve your goals.

Hordenine (N,N-dimethyltyramine):
Hordenine is one of the most favored stimulant ingredients in bodybuilding circles, and has been for some time. Users rave about hordenine, due to its structural similarity with several potent nootropics and stimulants within the phenethylamine class.

Though limited, some animal research suggest that hordenine may modulate certain brain and nervous system processes, and perhaps regulating the body's release of and response to noradrenaline.

Caffeine (1,3,7-trimethylxanthine) and (Theobromine (3,7-dimethyl-1H-purine-2,6-dione): Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.

Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning' of fat) actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source for the oxidative provision of ATP (your body's energy currency).

Evidence for caffeine's capacity as a lipolytic is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.

Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.

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